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Research in this area has included the development of simulation software, such as Nano CAD.
Despite its current early developmental status, there has been much speculation about the impact of nanotechnology on economics and law.
Specifically, the inputs to any such manufacturing process would be raw materials, energy, design software, and time.
For less speculative discussion of this potential, see the separate article on the molecular assembler.
Beyond that, there is war, even between prosperous states, and non-economic goals to consider.